Potentiation of Hepatic and Renal Toxicity of Various Compounds by Prior Exposure to Polybrominated Biphenyls
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چکیده
منابع مشابه
Potentiation of hepatic and renal toxicity of various compounds by prior exposure to polybrominated biphenyls.
Mice ingesting a standard rodent diet supplemented with polybrominated biphenyls (PBBs) were more susceptible to chlorinated hydrocarbon solvent-induced renal and hepatic damage, as well as the lethal effects of CHCl3 and CCl4, than were mice consuming control diet. As little as 0.025 ml/kg CHCl3 caused a significant increase in serum glutamic oxaloacetic transaminase (SGOT) and blood urea nitr...
متن کاملHuman exposure to polychorinated biphenyls and polybrominated biphenyls
Although the polychlorinated biphenyls (PCBs) have been used in a wide variety of industrial applications in the U. S. from 1930 until 1970, when their distribution was voluntarily restricted to closed systems, there is scant information on human exposure to adverse human health effects in the U. S. In the U. S., minimal human exposure of the population to PCBs is limited to food, air, and wate...
متن کاملThe human health effects of exposure to polybrominated biphenyls.
The Human Health Effects of Exposure to Polybrominated Biphenyls. STROSS, J. K., SMOKLER, I. A., ISBISTER, J., AND WILCOX, K. R. (1981). Toxicol. Appl. Pharmacol. 58, 145-150. Polybrominated biphenyls (PBB) were inadvertently introduced into the food chain in Michigan in 1973. Fifty-one people with known exposure to PBB were studied. Twenty-three farmers with disabling health complaints, and 28...
متن کاملToxicity of polybrominated biphenyls (PBBs) in Domestic and laboratory animals.
The composition, environmental fate, and effects of the polybrominated biphenyls (Firemaster BP-6 or FF-1) involved in the accidental contamination of cattle feed in Michigan in 1973 are reviewed. Toxic effects referred to in this report are limited to those occurring in domestic and laboratory animals and include general toxicity, neurobehavioral toxicity, immunotoxicity, reproductive toxicity...
متن کاملIncidence of thyroid disease following exposure to polybrominated biphenyls and polychlorinated biphenyls, Michigan, 1974-2006.
Thyroid hormones, which influence body metabolism and development, could be affected by persistent organic pollutants. We sought to examine the relationship between polybrominated biphenyls (PBBs) and polychlorinated biphenyls (PCBs) and thyroid disease. We employed incidence density sampling to perform a nested case control analysis of the Michigan Long-Term PBB Cohort. Cohort members (n=3333)...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1978
ISSN: 0091-6765
DOI: 10.2307/3428767